Post-traumatic stress disorder (PTSD) occurs after an individual has been exposed to a traumatic event. Symptoms of PTSD include flashbacks, nightmares and intrusive thoughts, avoidance of anything that reminds people of the original trauma and anxiety and jumpiness. A number of trials of selective serotonin reuptake inhibitors (SSRIs) have shown that these can be effective in treating PTSD but in recent years several studies have been published with ambiguous or even negative results and some negative trials remain unpublished. Now a new study of 411 patients in the U.S. has also found no significant difference between fluoxetine (an SSRI more familiarly known as Prozac) and a placebo.
Martenyi, Ferenc, Brown, Eileen B. and Caldwell, Catherine D. - Failed efficacy of fluoxetine in the treatment of posttraumatic stress disorder Journal of Clinical Psychopharmacology April 2007, 27(2), 166-170