The side effects of antipsychotic drugs can include changes in fats called lipids in the bloodstream, disturbances in blood glucose levels and weight gain all of which are part of a collection of changes called the metabolic syndrome which has been linked to type 2 (adult-onset) diabetes and heart disease. The precise link between the drugs and these metabolic changes are unclear but the effects can vary widely from person to person. A study of 112 people taking antipsychotics in Holland found that there was a link with a gene called HTR2C with those people having variations in the gene being more at risk of weight gain and metabolic changes.
Mulder, Hans ... [et al] - The association between HTR2C gene polymorphism and the metabolic syndrome in patients with schizophrenia Journal of Clinical Psychopharmacology August 2007, 27(4), 338-343
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