An Australian study looked into the effectiveness of oestrogen, combined with antipsychotic drugs, in the treatment of schizophrenia. The study included 102 women of child-bearing age with schizophrenia. For 28 days 56 of the women received 100 micrograms of estradiol daily via a skin patch while the rest of the women wore a placebo patch. The women's psychotic symptoms, including delusions and hallucinatory behaviour were assessed weekly and those taking estradiol showed a greater improvement in symptoms. However, the oestrogen treatment had no effect in improving the negative symptoms of schizophrenia.
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