Olanzapine is a drug used to treat schizophrenia. It has been associated with weight gain, insulin resistance, high cholesterol and diabetes. A study of 15 people with schizophrenia who were already taking olanzapine experimented with another drug called aripiprazole. Half the participants were given aripiprazole and half a placebo. After four weeks of aripiprazole treatment there were significant declines in weight and certain types of cholesterol. There were few side effects to adding the aripiprazole.
Henderson, David C. ... [et al] - Aripiprazole added to overweight and obese olanzapine-treated schizophrenia patients Journal of Clinical Pharmacology April 2009, 29(2), 165-169