Studies have found that a large percentage of depressed patients may have limited response and remission rates when treated with traditional antidepressants. There is increasing evidence in favour of the use of atypical antipsychotics in the treatment of depression and a review of the literature has found that olanzapine and risperidone have several controlled clinical trials indicating their effectiveness at doses lower than those used in treating psychoses. The review concluded that aripiprazole, olanzapine and risperidone are reasonable choices to add to anti-depressants in cases of treatment-resistant depression.
Philip, Noah S. ... [et al] - Augmentation of anti-depressants with atypical antipsychotics: a review of the current literature Journal of Psychiatric Practice January 2008, 14(1), 34-44
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