Early detection of Alzheimer's disease is crucial and researchers spend a lot of time trying to find tests that will help with diagnosis. Researchers at the Sahlgrenska Academy, part of the University of Gothenburg, studied the levels of substances in people's cerebrospinal fluid (CSF) and came up with a 'profile' of different indicators for people with Alzheimer's disease (CSF-AD). People with CSF-AD had a risk of deterioration 27 times greater than that of the control group and all the patients with mild cognitive impairment who went on to develop Alzheimer's had the CSF-AD profile. The profile also fitted in well with other factors related to the disease such as the presence of the APOE e4 gene and atrophy of the hippocampus.
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