Monday, July 27, 2009

Antidepressants for insomnia

It is estimated that between 50-70 million Americans suffer from either chronic sleep loss or a diagnosable sleep disorder with 10% of the population reporting not getting enough sleep to function effectively within any given month. Sleep hypnotics and benzodiazepines are the usual drugs for treating sleep problems but can have the potential to cause addiction and worse insomnia when they are withdrawn. Antidepressants can also be used to treat insomnia but not all antidepressants work in the same way and some can actually damage sleep quality. Joseph M. Holshoe from the University of Alabama reviewed the research into antidepressants and sleep. He found that the sedating tricyclic antidepressants such as amitriptyline, nortriptyline, doxepine and clomipramine all improved sleep quality while the stimulating tricyclics trimipramine, desipramine and protriptyline made it worse. Of the selective serotonin reuptake inhibitors (SSRIs) only escitalopram improved sleep quality; fluoxetine, paroxetine, citalopram, venlafaxine and duloxetine all made it worse. A category of drugs called serotonin-2 receptor antagonists/reuptake inhibtors (SARIs) had more beneficial effects with low doses of trazodone and nefazodone being found to be good treatments for insomnia. The effects of bupropion were unclear. Mirtazapine was found to improve sleep but was associated with day-time sleepiness and weight gain.

Holshoe, Joseph M. - Antidepressants and sleep: a review Perspectives in psychiatric care 45(3), 191-197

4 comments:

Srrawn said...

As an effective medicine, paxil would surely provide you immense relief if you are in the grip of panic disorder, depression or generalized anxiety disorder but it is altogether true that the usage of Paxil occasionally facilitates certain side-effects such as headache, low blood pressure, irregular heartbeat et al. These side-effects can yield serious results if not treated immediately hence take this medicine only on proper prescription.

Anonymous said...

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Michael Firth said...

What is going on? I purchased some Trip2night from narcomundo.com and it is in a powder now? What the heck! I bought it years ago and they were red capsules. I have not taken the new powder as of yet, it just came in the mail; and I am going to wait until I get some feed back to get a heads up on how much to take. The directions do not give a good explanation towards what I am looking for.

Anna Levand said...

People who have problems with sleeping most likely need help of a psychotherapist than of drugs


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