Researchers from the University of Thessaloniki and the University of Barcelona reviewed 181 studies into the effectiveness of the antipsychotic drug aripiprazole in treating bipolar disorder. They found that although it had little effect in the depressive phase of the illness it was useful in preventing and treating mania. The most frequent side effect was akathisia (an unpleasant sensation of restlessness with an inability to sit still or remain motionless).
Fountoulakis, Konstantinos N. and Vieta, Eduard - Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review Annals of General Psychiatry 2009, 8(16)
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