Neurological soft signs (NSS) are subtle motor and sensory deficits frequently found in people with schizophrenia. A German study of 64 people looked at the links between NSS and brain structure. They scanned 42 people with schizophrenia and 22 healthy controls and asked people to fill out a questionnaire designed to find out their NSS. The researchers found that NSS scores were significantly higher in patients than in the control group. NSS were significantly associated with reduced grey and white matter in the pre- and post-central gyrus, pre-motor area, middle and inferior frontal gyri, cerebellum, caudate nucleus and thalamus.
Thomann, P. A. ... [et al] - Neurological soft signs and brain morphology in first-episode schizophrenia Psychological Medicine March 2009, 39(3), 371-379