A review of newer antidepressants published in the Lancet looked at data from 117 studies. It found that sertraline (brand name Zoloft) and escitalopram (Lexapro) were the most effective and well-tolerated. The studies were carried out from 1991 to 2007 and involved more than 25,000 participants; 12 drugs were compared. Mirtazapine (Remeron) and venlafaxine (Effexor) were also more effective than the other drugs. Far more people remained on sertraline and escitalopram than on the other drugs.
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