Some studies have shown that antipsychotic drugs can reduce drinking among people with alcohol problems although the results from more rigorous clinical trials have been mixed. A study of 61 alcoholics in Philadelphia, U.S. divided them into two groups with half being given the antipsychotic drug quetiapine and half being given a placebo over a period of twelve weeks. 31% of people being given quetiapine managed to stay off alcohol for the time of the trial compared to just 6% of those being given the placebo. Quetiapine was particularly effective for more severe alcoholics who spent fewer days drinking and drank less after taking the drug.
Kampman, Kyle M. ... [et al] - A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of type A and type B alcoholism Journal of Clinical Psychopharmacology August 2007 27(4), 344-351