A study of 439 adolescents with depression in the U.S. compared the effectiveness of treating them with fluoxetine (Prozac), fluoxetine and cognitive behaviour therapy (CBT), CBT alone and a placebo. The most effective treatment was fluoxetine and CBT, followed by fluoxetine alone. CBT alone was no more effective than a placebo.
March, J., Silva, S. and Vitiello, B. - The Treatment for Adolescents with Depression Study (TADS) Journal of the Academy of Child and Adolescent Psychiatry 2006, 45: 1393-1403